Masumeh Saeidi Health Providers 2820-9192 6 1 2026 06 01 Health System Resilience in the Digital Era: From Data Repositories to Intelligent, Interoperable Infrastructures 19 21 246214 10.22034/hp.2026.588523.1084 EN Mahdi Derakhshi Dean of Information and Communication Technology Unit, Mashhad Municipality Fire and Safety Services Organization, Mashhad, Iran. Mohammad Saeedi M.S. in Software Engineering, Information and Communication Technology Unit, Mashhad Municipality Fire and Safety Services Organization, Mashhad, Iran. 0009-0004-3240-4728 Journal Article 2026 06 25 <span lang="EN">Health system resilience increasingly depends on digital architectures that support continuity of care, adaptive decision-making, and sustained performance during crises. Despite the rapid expansion of digital data collection, fragmentation and limited interoperability continue to constrain its utility. Resilient digital health systems require interoperable standards, embedded clinical decision support, distributed computing models, and implementation-ready policy frameworks. Fast Healthcare Interoperability Resources (FHIR) facilitates modular, machine-readable data exchange; clinical decision support systems (CDSS) convert data into timely, actionable insights; and edge computing enhances functionality and equity in low-connectivity settings. The World Health Organization’s SMART Guidelines bridge normative recommendations and machine-executable specifications, enabling the translation of policy into deployable digital solutions. Transitioning from passive data repositories to intelligent, interoperable infrastructures enhances system responsiveness, safety, and equity. Ultimately, resilience depends on the integration of standards, algorithms, workflows, and governance within a coherent digital ecosystem.</span> https://www.health-providers.ir/article_246214_0b6cd7b6fde35733ece8ad7a080c3a83.pdf